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Publications

Selected Publications

Sacai H, Sakoori K, Konno K, Nagahama K, Suzuki H, Watanabe T, Watanabe M, Uesaka N#, Kano M#.

Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex.

Nat Commun. 2020 Oct 12;11(1):5140. doi: 10.1038/s41467-020-18861-3.

# Co-Corresponding authors

Nagahama K, Sakoori K, Watanabe T, Kishi Y, Kawaji K, Koebis M, Nakao K,Gotoh Y, Aiba A, Uesaka N#, Kano M#. Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities.

Cell Rep. 2020 Sep 15;32(11):108126. doi:10.1016/j.celrep.2020.108126. PMID: 32937141.

# Co-Corresponding authors

Uesaka N#, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M#. Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum.

Neuron. 2018 Feb 21;97(4):796-805.e5. doi: 10.1016/j.neuron.2018.01.018. Epub 2018 Feb 1. PubMed PMID: 29398357. # Co-Corresponding authors

 

Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A, Watanabe M, Kano M.

Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain.

Science. 2014 May 30;344(6187):1020-3. doi: 10.1126/science.1252514. Epub 2014 May 15. PubMed PMID: 24831527.

Uesaka N, Mikuni T, Hashimoto K, Hirai H, Sakimura K, Kano M. Organotypic coculture preparation for the study of developmental synapse elimination in mammalian brain.

J Neurosci. 2012 Aug 22;32(34):11657-70. PubMed PMID: 22915109;  PubMed Central PMCID: PMC6703771.

Yamada A*, Uesaka N*, Hayano Y, Tabata T, Kano M, Yamamoto N.

Role of pre- and postsynaptic activity in thalamocortical axon branching.

Proc Natl Acad Sci U SA. 2010 Apr 20;107(16):7562-7. doi: 10.1073/pnas.0900613107. Epub 2010 Apr 5. PubMed PMID: 20368417; PubMed Central PMCID: PMC2867758. *authors contributed equally

Uesaka N*, Hayano Y*, Yamada A, Yamamoto N. Interplay between laminar specificity and activity-dependent mechanisms of thalamocortical axon branching. 

J Neurosci. 2007 May 9;27(19):5215-23. PubMed PMID: 17494708; PubMed Central PMCID: PMC6672371.

*authors contributed equally

Uesaka N, Hirai S, Maruyama T, Ruthazer ES, Yamamoto N. Activity dependence of cortical axon branch formation: a morphological and electrophysiological study

using organotypic slice cultures. J Neurosci. 2005 Jan 5;25(1):1-9. PubMed PMID: 15634761; PubMed Central PMCID: PMC6725200.

Publications: テキスト

Full Publications for N. Uesaka

 

Itami C, Uesaka N, Huang JY, Lu HC, Sakimura K, Kano M, Kimura F.

Endocannabinoid-dependent formation of columnar axonal projection in the mouse cerebral cortex. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2122700119. doi: 10.1073/pnas.2122700119. Epub 2022 Sep 6.

Nagahama K, Fujino S, Watanabe T, Uesaka N, Kano M. Combining
electrophysiology and optogenetics for functional screening of pyramidal neurons
in the mouse prefrontal cortex. STAR Protoc. 2021 Apr 15;2(2):100469. doi:
10.1016/j.xpro.2021.100469. PMID: 33937875; PMCID: PMC8079664.

Fleck D, Kenzler L, Mundt N, Strauch M, Uesaka N, Moosmann R, Bruentgens F,

Missel A, Mayerhofer A, Merhof D, Spehr J, Spehr M. ATP activation of peritubular cells drives testicular sperm transport. Elife. 2021 Jan 27;10:e62885. doi: 10.7554/eLife.62885. PMID: 33502316.

 

Yamashiro K, Hori K, Lai ESK, Aoki R, Shimaoka K, Arimura N, Egusa SF, Sakamoto A, Abe M, Sakimura K, Watanabe T, Uesaka N, Kano M, Hoshino M. AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication. iScience. 2020 Nov 18;23(12):101820. doi: 10.1016/j.isci.2020.101820. PMID: 33305180; PMCID: PMC7708818.

 

Sacai H, Sakoori K, Konno K, Nagahama K, Suzuki H, Watanabe T, Watanabe M, Uesaka N, Kano M.

Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex. Nat Commun. 2020 Oct 12;11(1):5140. doi: 10.1038/s41467-020-18861-3.

PMID: 33046712; PMCID: PMC7552417.

 

Nagahama K, Sakoori K, Watanabe T, Kishi Y, Kawaji K, Koebis M, Nakao K, Gotoh Y, Aiba A, Uesaka N, Kano M.

Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities. Cell Rep. 2020 Sep 15;32(11):108126. doi:

10.1016/j.celrep.2020.108126. PMID: 32937141.

 

Nagumo Y, Ueta Y, Nakayama H, Osaki H, Takeuchi Y, Uesaka N, Kano M, Miyata M. Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations. Cell Rep. 2020 Jun 23;31(12):107797. doi: 10.1016/j.celrep.2020.107797. PMID: 32579924.

Rai Y, Watanabe T, Matsuyama K, Sakimura K, Uesaka N, Kano M. Phospholipase Cβ3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum. Neuroscience. 2020 Apr 29:S0306-4522(20)30268-2. doi: 10.1016/j.neuroscience.2020.04.035. Epub ahead of print. PMID: 32360594.

Saito R, Koebis M, Nagai T, Shimizu K, Liao J, Wulaer B, Sugaya Y, Nagahama K, Uesaka N, Kushima I, Mori D, Maruyama K, Nakao K, Kurihara H, Yamada K, Kano M, Fukada Y, Ozaki N, Aiba A. Comprehensive analysis of a novel mouse model of the 22q11.2 deletion syndrome: a model with the most common 3.0-Mb deletion at the human 22q11.2 locus. Transl Psychiatry. 2020 Feb 5;10(1):35. doi: 10.1038/s41398-020-0723-z. PMID: 32066675; PMCID: PMC7026107.

Kano M, Watanabe T, Uesaka N, Watanabe M. Multiple Phases of Climbing Fiber Synapse Elimination in the Developing Cerebellum. Cerebellum. 2018 Dec;17(6):722-734. doi: 10.1007/s12311-018-0964-z. PMID: 30009357.

Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M. Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum. Neuron. 2018

Feb 21;97(4):796-805.e5. doi: 10.1016/j.neuron.2018.01.018. Epub 2018 Feb 1.

PMID: 29398357.

Uesaka N, Kano M. Presynaptic Mechanisms Mediating Retrograde Semaphorin Signals for Climbing Fiber Synapse Elimination During Postnatal Cerebellar Development. Cerebellum. 2018 Feb;17(1):17-22. doi: 10.1007/s12311-017-0888-z. PMID: 28965326.

Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M. Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum. Nat Commun. 2017 Aug 4;8(1):195. doi: 10.1038/s41467-017-00260-w. PMID: 28775326; PMCID: PMC5543168.

Watanabe T, Uesaka N, Kano M. [Mechanisms of synapse pruning in the developing cerebellum]. Seikagaku. 2016 Oct;88(5):621-9. Japanese. PMID: 29624329.

Narushima M, Uchigashima M, Yagasaki Y, Harada T, Nagumo Y, Uesaka N, Hashimoto K, Aiba A, Watanabe M, Miyata M, Kano M. The Metabotropic Glutamate Receptor Subtype 1 Mediates Experience-Dependent Maintenance of Mature Synaptic Connectivity in the Visual Thalamus. Neuron. 2016 Sep 7;91(5):1097-1109. doi: 10.1016/j.neuron.2016.07.035. Epub 2016 Aug 18. PMID: 27545713.

Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart

I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi

N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E,

Schilling K, Sekerková G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ,

Hawkes R. Consensus Paper: Cerebellar Development. Cerebellum. 2016

Dec;15(6):789-828. doi: 10.1007/s12311-015-0724-2. PMID: 26439486; PMCID:

PMC4846577.

 

Uesaka N, Uchigashima M, Mikuni T, Hirai H, Watanabe M, Kano M. Retrograde

signaling for climbing fiber synapse elimination. Cerebellum. 2015

Feb;14(1):4-7. doi: 10.1007/s12311-014-0615-y. PMID: 25338972.

 

Uesaka N, Kawata S, Kano M. [Cellular and molecular mechanisms of synapse

elimination in the Mammalian brain]. Brain Nerve. 2014 Sep;66(9):1069-77.

Japanese. PMID: 25200578.

 

Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, Aiba A,

Watanabe M, Kano M. Retrograde semaphorin signaling regulates synapse

elimination in the developing mouse brain. Science. 2014 May

30;344(6187):1020-3. doi: 10.1126/science.1252514. Epub 2014 May 15. PMID:

24831527.

 

Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, Kano M.

Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination

in the developing cerebellum. Neuron. 2013 Jun 19;78(6):1024-35. doi:

10.1016/j.neuron.2013.04.036. PMID: 23791196; PMCID: PMC3773328.

 

Uesaka N, Mikuni T, Hashimoto K, Hirai H, Sakimura K, Kano M. Organotypic

coculture preparation for the study of developmental synapse elimination in

mammalian brain. J Neurosci. 2012 Aug 22;32(34):11657-70. doi:

10.1523/JNEUROSCI.1097-12.2012. PMID: 22915109; PMCID: PMC6703771.

 

Tanimura A, Uchigashima M, Yamazaki M, Uesaka N, Mikuni T, Abe M, Hashimoto

K, Watanabe M, Sakimura K, Kano M. Synapse type-independent degradation of the

endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12195-200. doi:

10.1073/pnas.1204404109. Epub 2012 Jul 10. PMID: 22783023; PMCID: PMC3409771.

 

Sugo N, Oshiro H, Takemura M, Kobayashi T, Kohno Y, Uesaka N, Song WJ,

Yamamoto N. Nucleocytoplasmic translocation of HDAC9 regulates gene expression

and dendritic growth in developing cortical neurons. Eur J Neurosci. 2010

May;31(9):1521-32. doi: 10.1111/j.1460-9568.2010.07218.x. PMID: 20525066.

 

Yamada A, Uesaka N, Hayano Y, Tabata T, Kano M, Yamamoto N. Role of pre- and

postsynaptic activity in thalamocortical axon branching. Proc Natl Acad Sci U S

A. 2010 Apr 20;107(16):7562-7. doi: 10.1073/pnas.0900613107. Epub 2010 Apr 5.

PMID: 20368417; PMCID: PMC2867758.

 

Ohnami S, Endo M, Hirai S, Uesaka N, Hatanaka Y, Yamashita T, Yamamoto N.

Role of RhoA in activity-dependent cortical axon branching. J Neurosci. 2008 Sep

10;28(37):9117-21. doi: 10.1523/JNEUROSCI.1731-08.2008. PMID: 18784292; PMCID:

PMC6670927.

 

Yamamoto N, Maruyama T, Uesaka N, Hayano Y, Takemoto M, Yamada A. Molecular

mechanisms of thalamocortical axon targeting. Novartis Found Symp.

2007;288:199-208; discussion 208-11, 276-81. doi: 10.1002/9780470994030.ch14.

PMID: 18494260.

 

Uesaka N, Nishiwaki M, Yamamoto N. Single cell electroporation method for

axon tracing in cultured slices. Dev Growth Differ. 2008 Aug;50(6):475-7. doi:

10.1111/j.1440-169X.2008.01024.x. Epub 2008 Apr 16. PMID: 18422686.

 

Uesaka N, Hayano Y, Yamada A, Yamamoto N. Interplay between laminar

specificity and activity-dependent mechanisms of thalamocortical axon branching.

J Neurosci. 2007 May 9;27(19):5215-23. doi: 10.1523/JNEUROSCI.4685-06.2007.

PMID: 17494708; PMCID: PMC6672371.

 

Uesaka N, Ruthazer ES, Yamamoto N. The role of neural activity in cortical

axon branching. Neuroscientist. 2006 Apr;12(2):102-6. doi:

10.1177/1073858405281673. PMID: 16514007.

 

Uesaka N, Hirai S, Maruyama T, Ruthazer ES, Yamamoto N. Activity dependence

of cortical axon branch formation: a morphological and electrophysiological

study using organotypic slice cultures. J Neurosci. 2005 Jan 5;25(1):1-9. doi:

10.1523/JNEUROSCI.3855-04.2005. PMID: 15634761; PMCID: PMC6725200.

Publications: テキスト
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